The American Voice Institute of Public Policy Presents

Personal Health

Joel P. Rutkowski, Ph.D., Editor
August 20, 2002

 

 

 

Important Medical Disclaimer: The content displayed in Personal Health is designed to educate and inform. Under no circumstances is it meant to replace the expert care and advice of a qualified physician. Rapid advances in medicine may cause information contained here to become outdated, invalid or subject to debate. Accuracy cannot be guaranteed. Personal Health assumes no responsibility for how information presented is used.

Personal Health for the Week of August 10 -- 16


FRIDAY, AUGUST 16, 2002 

Report: Water Diseases On Rise

By Colleen Valles

Associated Press Writer

The Associated Press

Friday, August 16, 2002

As many as 76 million people — mostly children — could die from water-related diseases by 2020 if changes aren't made worldwide, according to a California think tank.

The United Nations ( news - web sites) has set a goal of 2015 for cutting in half the number of people who can't reach or afford safe drinking water. Even if that goal is met, 34 million to 76 million people could die of water-related illnesses, said a report for release Friday by the independent Pacific Institute for Studies in Development, Environment and Security.

More people die of diarrheal diseases, such as dysentery, than other water-related diseases, and children are extremely vulnerable to them.

"All of these diseases are associated with our failure to provide clean water," said Dr. Peter Gleick, director of the institute. "I think it's terribly bleak, especially because we know what needs to be done to prevent these deaths. We're doing some of it, but the efforts that are being made are not aggressive enough."

The problem is many people, especially those in developing countries in sub-Saharan Africa and southern Asia, don't have access to clean water or basic sanitation, Gleick said.

While most of the deaths are projected to occur in developing nations, Joan Rose, professor of water microbiology at the University of South Florida, said every country is vulnerable. She pointed to a recent deadly outbreak of E. coli in Canada that came from a contaminated well.

"We look at our political agreements like NAFTA, and they've been economically beneficial to South America because we have allowed them to export their vegetables to the United States," she said. "But none of that finance has been reinvested in sanitation, and in fact, we may be getting vegetables — we already have — that bring diseases into the United States."

The United Nations says 1.1 billion people worldwide live without access to safe drinking water and 2.5 billion lack proper sanitation.

The institute will send the report to the World Summit on Sustainable Development being held Aug. 26 through Sept. 4 in Johannesburg, South Africa.

On the Net:

Pacific Institute for Studies in Development, Environment and Security: www.pacinst.org

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CDC Team Gauges Risk of West Nile Spread Via Blood

By Mary Beth Nierengarten

Reuters Health

Friday, August 16, 2002

NEW YORK (Reuters Health) - West Nile virus ( news - web sites) infection, the mosquito-borne illness now spreading across the US, could be transmitted through blood transfusions, researchers from the Centers for Disease Control and Prevention ( news - web sites) (CDC) report.

But the risk--while relatively high--would only exist for blood donated during peak times of infection, they conclude.

West Nile virus is carried by certain birds, and can be passed to humans via mosquitoes. The virus--which originated in Africa and was first spotted in the United States in New York in 1999--has quickly spread west and south across the US.

West Nile risk would be highest for blood donated at times and places when the infection was most common--for example the northeastern US in late August, the CDC researchers say. If patients given blood that was donated during such periods exhibit West Nile virus-like symptoms, they add, doctors should consider the possibility that the patient has contracted the infection from the blood donation.

It is particularly important to determine if West Nile could be spread by transfusion, Dr. Brad J. Biggerstaff from the CDC's National Center for Infectious Diseases in Fort Collins, Colorado and Lyle R. Petersen note, because people infected with the virus usually don't have symptoms. But among those who do develop severe illness, fatalities range from 3% to 30%, with the highest death rate among the elderly. There is no cure for the infection.

To investigate the theoretical risk that West Nile virus could be spread by donated blood from infected individuals, Biggerstaff and Petersen conducted a statistical analysis of the 1999 outbreak in Queens, New York. They report the findings in the August issue of the journal Transfusion.

The researchers examined the date of onset for people infected with the West Nile virus during the 1999 epidemic and estimated the number of people who had the virus in their blood throughout the outbreak. To infer the transfusion-transmission risk based on these data, the investigators then estimated the inapparent-to-apparent infection ratio, the proportion of asymptomatic infections, and the size of the population.

The minimum risk of a donor transmitting the West Nile virus through his or her blood during the 1999 outbreak was found to be 1.8 in 10,000 donations, with a maximum risk of 2.7. The risk of transmission was time-limited, peaking during the months of August and September, the period in the northeastern US with the highest rate of infections. Estimates of infection entering the blood supply before August or after September fell to nearly zero.

Elsewhere in the US, the time of highest activity of West Nile virus may start earlier, Biggerstaff noted, "as with the current outbreak in Louisiana. In other parts of the US where West Nile virus is new, we just don't know yet."

Although the estimates indicate a theoretically low risk of transmitting the West Nile virus through transfusion, they are relatively high compared to transfusion-transmitted viruses regularly screened for, such as HIV ( news - web sites). Estimates for HIV, for example, range from 1 per 200,000 to 2 million.

"While the estimates we give are relatively high," explained Biggerstaff, "it's important to remember that the average rate we give is during the outbreak only and for the area of the outbreak only, and that the rate is lower outside this time frame and locale."

Implications of this study suggest that doctors should consider the possibility of transfusion-transmitted West Nile virus in patients with unexplained symptoms suggestive of this virus, particularly if the blood donation was obtained when the activity of the virus is highest. "But they should also be aware of the level of risk or chance of such an occurrence when making a clinical decision," Biggerstaff added.

Source: Transfusion 2002;42:1019-1026.  

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Smoking During Pregnancy Increases Kid's Asthma Risk

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews) -- Children whose mothers smoked during pregnancy have an increased chance of getting asthma if they don't have a certain type of enzyme.

The enzyme also exists as a variation, and the variation is so common in children that it affects the ability of the lungs to protect themselves, according to a study in the latest edition of the American Journal of Respiratory and Critical Care Medicine. And if mothers were smoking while they were pregnant, their children were more susceptible to asthma and other respiratory illnesses, the researchers conclude.

The variation involves a gene called glutathione S-transferase M1 (GSTM1), which creates an enzyme that helps the lungs protect themselves from pollutants. The enzyme detoxifies some tobacco pollutants and defuses oxidants before they can damage lung tissue.

Children with the GSTM1 null genotype who were exposed to cigarette smoke while in the womb were much more likely to have asthma, wheezing and breathing-related emergency room visits compared to children with the GSTM1 present genotype, the study says.

Researchers at the Keck School of Medicine at the University of Southern California studied 2,950 children in grades 4, 7 and 10. Their parents were asked about whether the mother smoked when she was pregnant, and whether their kids had suffered breathing problems.

More than 16 percent of the children had mothers who smoked during pregnancy, and more than 45 percent of the children had the GSTM1 null genotype.

When the researchers looked at the children with the null genotype whose mother smoked during pregnancy they found:

  • Almost a four-fold increased risk for emergency room visits within the past year.
  • More than a double risk for wheezing with exercise and wheezing requiring medication.
  • An 80 percent increased risk for a lifetime history of wheezing.
  • 70 percent and 60 percent increased risks for asthma with current symptoms and early onset, asthma, respectively.

There was no increased risk for respiratory problems in children with the GSTM1 present genotype who were exposed to cigarette smoke in the womb.

"Findings show that exposure to smoke in the womb for certain genetically susceptible children may have long-term health effects," says study author Dr. Frank D. Gilliland, professor of preventive medicine.

"Maternal smoking is common, and the null genotype is found in nearly half of the population, so this high-risk group might be an important population to target for prevention," he says.

More information

Nicotine addition is one of the hardest habits to kick. But if ever there was reason to quit, pregnancy has to be at the top of the list.

This useful question-and-answer page from the American Lung Association explains the risks a woman runs by continuing to smoke during pregnancy.

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Stimulation Boosts Brain Cells in Aging Mice: Study

Reuters Health

Friday, August 16, 2002

NEW YORK (Reuters Health) - A stimulating environment in middle to late life may be just the trick to bolster a region of the brain associated with memory and learning, according to the results of a study in mice.

"It is common sense and backed by epidemiological data that to lead an 'active' life is beneficial for mind and brain," report Dr. Gerd Kempermann of Humboldt University in Berlin, Germany and colleagues.

However, the study authors note that there is a dearth of scientific evidence about what's happening at a cellular level in the stimulated brain.

In their study, published in the August issue of Annals of Neurology, the research team studied 10- to 20-month-old mice. The animals were middle-aged to elderly, as most mice go through menopause at 10 to 13 months of age and generally have a life span of 2 years.

One group of mice lived in standard cages and the other lived in "enrichment housing"--cages filled with running wheels, tunnels, toys and choices of food.

After 10 months, mice living in the enriched environment were found to have five times the number of new brain cells in their hippocampus--a region of the brain associated with memory and learning--as mice living in bland surroundings. What's more, the mice in the standard cages had 50% more cells containing aging-related deposits as rodents living in the enriched environment.

The results, according to the authors, suggest that enriched environments may help the brain maintain a certain level of plasticity, which in turn could keep memory and mental function intact as a person ages.

Nonetheless, Kempermann and colleagues note that "the concept of environmental enrichment in studies with inbred rodents cannot be easily applied to the human condition."

Source:  Annals of Neurology 2002;52:135-143.

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Mohs Surgery: Gold Standard for Skin Cancer

By Irene S. Levine
HealthScoutNews Reporter

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews) -- It's called the Mohs procedure, and it's considered the gold standard for treating many skin cancers, but few people have ever heard of it.

Some doctors think the painstaking procedure is not always necessary, but surgeons trained in the practice note it's critical to remove tumors completely the first time around since they're tougher to treat if they return.

According to the American Cancer Society ( news - web sites), about 1.3 million cases of non-melanoma skin cancer are diagnosed each year. In 2002 alone, 2,200 people will die of these cancers.

The good news is this type of skin cancer is almost 100 percent treatable when found early. The goal of treatment is to remove or destroy the cancer completely, with as small a scar as possible.

Options include surgery, curettage and electrodessication, cryosurgery, laser therapy, radiation and topical chemotherapy and Mohs surgery.

Over the past 30 years, a growing number of patients and doctors are opting for the Mohs technique, which was first developed by Dr. Frederic Mohs at the University of Wisconsin in 1936.

"It's a relatively new surgical procedure in medicine, but it has now become the standard of care for certain tumors," says Dr. Matthew Brett Quan, a Mohs surgeon at the Center for Dermatology, Cosmetic and Laser Surgery in Mount Kisco, N.Y. Quan spent a year studying the procedure, and has been a Mohs surgeon since 1996.

The Mohs procedure is used when a doctor doesn't know the shape or depth of a tumor; when the tumor is in a hard-to-treat area such as the nose, eyelid or face; or when the tumor is a recurrence. In these instances, many insurers will cover the costs of the procedure.

Surgery generally takes place in an outpatient setting. After applying a local anesthetic to the affected area of the skin, the Mohs surgeon removes a thin layer of skin, marks its location, and examines it under a microscope.

The tissue is mapped on a color-coded grid so the surgeon can pinpoint the corresponding location on the wound. If cancerous tissues are still found, the process is repeated until the slides are cancer-free.

Because it can take up to an hour to examine each slide, the procedure can take half a day or more to complete. If the tumor is extensive, it may take more than a day.

The major difference between the Mohs technique and conventional surgery is the precision achieved by using the microscope to inspect samples of skin. This conservative approach maximizes the saving of healthy tissue, resulting in faster healing and better cosmetic results. Reconstructive surgery isn't needed unless the wound is very large.

However, unless a patient has had skin cancer before or knows someone who has, how likely are they to find a Mohs surgeon or look for one?

"Unfortunately you totally rely upon your dermatologist, your family practitioner, or whoever did your biopsy to tell you where to go and what to do," Quan says.

He suggests patients educate themselves through the Internet, and cautions that some dermatologists are doing the procedure with only minimal training.

Dr. Robert Greenberg is a dermatologist in Vernon, Conn., and a member of the American Academy of Dermatology. He believes the surgery is appropriate under certain circumstances and refers patients, as necessary, to qualified Mohs surgeons. However, he says many non-melanoma skin cancers can be treated adequately with conventional techniques.

"These procedures are much less costly, less invasive and easier on the patient," Greenberg says.

Moh's is time-consuming, labor-intensive and generally costs more than twice the price of any treatment except radiation, leading some critics to call the procedure "fee-effective."

Quan disagrees: "You get a smaller scar and a higher cure rate. Why not do it? They're harder to get out the second time around."

What To Do

Visit the Mohs College of Surgeons for more on the procedure and how to find Mohs surgeons.

The American Academy of Dermatology has more on skin cancer.

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Alcohol Initially Packs Bigger Punch for Some

By Keith Mulvihill

Reuters Health

Friday, August 16, 2002

NEW YORK (Reuters Health) - People with a family history of alcoholism may respond more intensely to alcohol's initial intoxicating effects and develop a tolerance within a few hours, new study finding suggest.

This may cause them to drink more alcohol so they can get back the initial buzz they were feeling when they first started drinking, explained Dr. Sandra L. Morzorati of the Indiana University School of Medicine in Indianapolis, in an interview with Reuters Health.

In the current investigation, Morzorati and colleagues wanted to know how people with a family history of alcoholism respond to feelings of intoxication compared to those from families without the drinking disorder. Their study results are published in the August issue of the journal Alcoholism: Clinical and Experimental Research.

To do so, the team looked at 58 adults who had at least two members of their family--be it a parent, sibling, cousin, aunt or uncle--that were alcoholics and compared them with 58 adults from non-alcoholic families. None of the participants were alcoholics themselves.

The researchers administered alcohol directly into the participants' blood and gave them breath tests that measured the amount of alcohol in their system. Blood alcohol levels were held constant at 0.06, slightly below the legal limit of 0.08.

After 20 minutes, those with a family history of alcoholism reported "more intense levels of intoxication" compared to the other group, Morzoroti explained. "At 2 hours, when they had adapted to the alcohol, they were not feeling as big of a punch as they were after just 20 minutes," she said.

The experiment, noted the researcher, revealed that people with a greater risk of alcohol dependence appear to have a distinct response to moderate alcohol consumption.

"It's been known for some time that people with a family history of alcohol (abuse) are more likely to have a genetic predisposition for alcoholism. The findings of our study support that further," she said.

Source: Alcoholism: Clinical and Experimental Research 2002;26:1299-1305.

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How Much Water Should You Drink?

By Adam Marcus
HealthScoutNews Reporter

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews)-- The mantra on daily water consumption may be a washout.

When you ask for advice on how much of the clear, cool liquid you should swig each day, there's a good chance you'll hear the following: At least eight 8-ounce glasses, or 64 ounces, of water each day.

But a New Hampshire doctor says that advice is hogwash, a national myth with no basis in physiologic fact.

Dr. Heinz Valtin, of Dartmouth Medical School, has researched the matter of adequate water intake and found a desert of evidence in support of the "8 x 8" theory.

Instead, Valtin says, those 64 ounces a day will get you little farther than the bathroom. In rare cases, people who drink too much may suffer "water intoxication" by overloading their kidneys. This phenomenon has been seen in athletes, Ecstasy users and even healthy people.

True, some of us may indeed need that half-gallon of water on some days -- when we're working out in the heat or flying for long distances in a dry airplane cabin. However, those situations appear to be the exceptions, not the norm.

"I have found no scientific proof that absolutely every person must drink at least eight glasses of water a day," says Valtin, a kidney specialist, in a statement. His review of the subject appears in the latest Internet edition of the American Journal of Physiology.

Valtin says the 64 ounces-a-day figure might have been a bastardization of recommendations from the National Research Council ( news - web sites)'s Food and Nutrition Board, which in 1989 called for roughly a milliliter of water coming in for every calorie of energy expended.

However, the guidelines go on to state that most of that amount -- 64 ounces to 80 ounces, on average -- can be obtained in prepared foods that are rich in fluids.

Items like juice, milk, soda and coffee are almost entirely water and may be reasonable substitutes for glasses of the plain stuff, Valtin says.

Yet, while the origins of the 8 x 8 myth are murky, the booming bottled water industry is clearly a driving force behind its promotion. Witness water.com, which boasts of being "the first e-commerce site for the purchasing and delivery of high quality spring water."

A "Live Healthy" section of the site, part of the Suntory Water Group in Atlanta, declares that "most experts agree that eight 8-ounce glasses is a good rule of thumb. But every individual has his or her own needs, and the amount of water needed from person to person varies, depending on their weight and level of activity."

However, it seems the only variable is how much more than 64 ounces a day you need. On a water intake calculator water.com provides, a 160-pound person who got no exercise is advised to drink 80 ounces, or between six and seven 12-ounce glasses, a day. Adding a 20-minute workout to the routine ups that figure to 84 ounces.

Stephen Kay, a spokesman for the International Bottled Water Association, says the 8 x 8 recommendation "certainly was not invented by the bottled water industry, nor is it a bottled water issue only. The issue overall is really water and water consumption" for proper hydration.

While a variety of foods have fluids, Kay says water is the "most direct source" of, well, water. It also happens to be free of calories, caffeine and other potentially undesirable substances. A statement on the group's Web site in response to Valtin's paper says it "remains supportive" of the 8 x 8 guidelines.

The Food and Nutrition Board is now reviewing daily water consumption. Its recommendations should be released in March 2003, says Paula Trumbo, a nutritionist who's in charge of the project.

Trumbo says her group is not relying on Valtin's paper, since it's a review not a study. However, she adds she agrees so far with his conclusion that there's little data supporting the conventional water wisdom.

"No one really knows the scientific basis for" the 8 x 8 rule, Trumbo says. "It's kind of hard to say whether it's credible or not."

The panel is conducting a study to clear up the question of how much water a person needs. Whatever answer emerges is sure to vary by weight or climate, for example, she says.

They're also looking at how, if at all, water intake affects certain health outcomes, from kidney stones to heart ailments, and whether the fluid in foods such as fruits and vegetables is an adequate source of H2O.

"We will be very specific in saying what this value is for," Trumbo says.

What To Do

For more on water and health, try the University of Iowa. For the water industry's perspective, visit the International Bottled Water Association.

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Obesity Linked to Increased Breast Cancer Rates in Hispanic Women

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews) -- Obesity may be a contributing factor to increasing cases of breast cancer ( news - web sites) among Hispanic women.

While Hispanic women have been known to be at lower risk than most other women for developing breast cancer, the rates are climbing, according to a study in the August issue of the Annals of Epidemiology. The increasing risk of breast cancer for Hispanic women before and after menopause may be due to the weight they gain in adulthood and their percentage of body fat, the research suggests.

It was done by scientists from the University of Southern California (USC), the University of New Mexico and Johns Hopkins University.

This is the first study to examine the relationship between weight and breast cancer risk in Hispanic women.

"We know that breast cancer incidence and mortality have been rising in Hispanic women, but no one knows why," lead investigator Dr. Frank D. Gilliland, assistant professor of medicine, USC's Keck School of Medicine, says in a statement.

"The thought was that perhaps these women were starting to have fewer children, have having them later in life, which may increase risk. But we looked at all the major reproductive factors, and they explained only 5 percent of the increase in risk. Something else must be going on," Gilliland adds.

The study included more than 1,500 Hispanic and non-Hispanic white women with breast cancer in New Mexico in the early 1990s. The researchers collected information about the women's current weight, their weight at age 18, menopausal status and use of hormone replacement therapy.

They found that obese Hispanic women had nearly twice the risk of breast cancer, and that risk was greater regardless of whether they had gone through menopause. Obese non-Hispanic white women had increased breast cancer risk only after menopause.

Hispanic women whose weight at the time of the study was more than 30 pounds heavier than their weight at age 18 more than doubled their risk of breast cancer.

The study also found that breast cancers linked to weight gain in Hispanic women and post-menopausal non-Hispanic white women mostly were estrogen- and progesterone-receptor positive. Also, breast cancer risk was higher in women who never used estrogen and who gained the most weight.

Obesity in Hispanic women increased 80 percent from 1991 to 1998, the study says, with about 25 percent of that population being classified as obese.

More information

Weight gain among Hispanic women also poses a risk for polycystic ovarian syndrome, as this article from Columbia University indicates.  

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Epidurals Don't Cause Long-Term Back Pain

By Kathleen Doheny
HealthScoutNews Reporter

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews) -- Epidurals, used for pain relief during labor, don't seem to cause the back problems later on that many women fear.

British researchers have found no significant differences in self-reported low back pain or disability in women who received epidurals and those who got other kinds of labor pain relief. The report appears in tomorrow's issue of the British Medical Journal.

The researchers assigned 369 first-time mothers-to-be either to a group that received an epidural for pain relief or to a group that got various other forms of pain relief. An epidural is a local anesthetic, delivered in the small of the back, just outside the spinal canal. It lets a woman remain conscious during childbirth.

Then, they asked the women to participate in a follow-up study to track back pain and other problems; 151 from the epidural group and 155 from the non-epidural group participated. The researchers say they were prompted to do the study because several studies on back pain and epidurals have produced inconsistent results.

"We found no real surprises, and the study merely confirmed what we already suspected: that there was no causal association between epidurals for labor and long-term backache," says lead author Dr. Charlotte Howell, a consultant anesthetist at the North Staffordshire Hospital Trust, in Stoke on Trent, Staffordshire.

"But it was interesting to see how similar the groups were in terms of the results," Howell adds.

Back pain, however, was common in both groups, who were interviewed an average of 26 months after giving birth. More women in the epidural group reported severe pain, the researchers found. However, pain lasting more than a year was more common among the women who did not receive an epidural, with 64 women in the non-epidural group having pain for more than a year and 47 of those in the epidural group having pain that long.

"It is highly likely that long-term backache following pregnancy is due to the pregnancy itself," Howell says. "But this is difficult to establish because many women have back pain and many women also use epidurals. They tend to associate the two, and this will probably continue to be the case."

Women wondering what pain relief is best for them during labor should consult their anesthesiologist. "There is rarely a good reason to advise a woman against an epidural for labor, and no evidence to suggest that epidurals make established back pain worse," Howell adds.

Anesthesia experts have mostly praise for the study.

"This is an obvious finding for those of us who practice in this arena," says Christopher Stein, president of the California Association of Nurse Anesthetists who works in pain management and has experience in obstetrical pain relief.

Still, he says the study may help dispel misconceptions about epidurals that persist among some women, who may avoid them due to what they mistakenly think is a higher risk for lower back pain.

"The study has a good random sample," Stein adds.

However, he does see a few flaws. "They didn't control for who was doing the epidural," he says, although he concedes that would be difficult to do. Still, the skill of the operator, he adds, can make a difference. Also, they didn't ask about preexisting back pain.

"Epidurals are very safe," adds Dr. Michael Ferrante, an anesthesiologist at Santa Monica-UCLA Medical Center and co-director of the UCLA Spine Center. "There is no trauma, except to the soft tissue and that heals within two weeks or so."

He often hears concerns about epidurals raising the risk of low back pain, but tells patients it is "pure superstition."

The latest study, he says, "is nice, though a little bit flawed." He, like Stein, points out the researchers did not control for preexisting back pain.

What To Do

For information on different forms of pain relief during childbirth, see The American Association of Nurse Anesthetists or the http://www.asahq.org/PublicEducation/childbirth.pdf"; American Society of Anesthesiologists.

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Nothing Corny About It -- It's Good For You

HealthScoutNews

Friday, August 16, 2002

FRIDAY, Aug. 16 (HealthScoutNews) -- Here's a kernel of good news about sweet corn you can share with friends and neighbors at your next corn roast.

Whether you eat it on the cob, steam it, or cream it, cooking sweet corn unleashes beneficial nutrients that can substantially reduce your risk of heart disease and cancer, Cornell University food scientists report in the current issue of Journal of Agriculture and Food Chemistry.

When you cook sweet corn, you actually boost its antioxidant activity, their study says.

"There is a notion that processed fruits and vegetables have a lower nutritional value than fresh produce," says lead author Rui Hai Liu, assistant professor of food science. "Those original notions seem to be false, as cooked sweet corn retains its antioxidant activity, despite the loss of vitamin C."

Liu and his colleagues cooked sweet corn kernels in batches at 239°F for 10, 25 and 50 minutes. They found the antioxidants in the corn kernels increased by 22, 44 and 53 percent, respectively.

Antioxidants are substances that protect you against free radicals, which cause damage to your body from oxidation. Free radicals increase the risk of cancer and heart disease and have been linked to age-related diseases such as cataract and Alzheimer's disease ( news - web sites).

More information

This article from the BBC's Web site explains why vegetables sometimes are more beneficial cooked than raw.

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Need a Specialist? Chance of Referral Higher in US

Reuters Health

Friday, August 16, 2002

NEW YORK (Reuters Health) - Patients are twice as likely to receive referrals to see a medical specialist in the US as in the UK, new study findings show.

Dr. Christopher B. Forrest of Johns Hopkins University in Baltimore, Maryland, and his colleagues found that, overall, between 30% and 37% of Americans received referrals to see a specialist, relative to only 14% of patients in the UK.

These results do not reflect nationwide differences in how sick people are, the authors note; factoring the severity of a patient's illness into the comparison did not change the result. Specifically, the sickest patients in the UK were still half as likely to receive referrals as US patients with an illness that was just as severe.

There are many more medical specialists in the US than in the UK, Forrest's group notes, a trend that may play a large role in these results.

"The low availability of specialists, and resultant long waiting lists, in the United Kingdom is an important explanation for these differences," the authors write.

Forrest and colleagues obtained their results from the percentage of patients who received new referrals to visit a medical specialist during 1996 in the US, and 1997 in the UK. In the UK, general practitioners would record if a patient received a referral, while in the US, the investigators measured referral rates by the percentages of patients who visited a specialist for the first time at least once.

The data are based on a sample of 384,693 Americans and 757,680 people from the UK.

With relatively few specialists in the UK, patients often need to wait for long periods of time before receiving treatment, an aspect of medical care that may discourage UK physicians from giving patients referrals, the authors suggest. As an illustration, only 1% of US patients wait at least 4 months for elective surgery, an experience forced on 33% of patients in the UK.

"Absence of waits is likely to have lowered the US physicians' referral thresholds," Forrest and his team write.

In addition, the researchers note, many UK physicians may also have a "less intensive" style of practicing medicine than those in the US, a trait that may help explain why they are less likely to write referrals. Americans are also more likely than UK patients to refer themselves to a specialist, without seeking their doctors' permission, Forrest and his colleagues point out.

Source: British Medical Journal 2002;325:370-371.

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MSG Myths

HealthScoutNews

Friday, August 16, 2002

 (HealthScoutNews) -- If you think Chinese takeout causes you headaches because of all the monosodium glutamate (MSG) that's used to bring out the flavor of various foods, you'll be surprised at this Harvard study.

According to the Journal of Nutrition, MSG may not cause headaches after all.

University researchers found 130 people who complained of MSG headaches and got them to try foods with and without MSG. They also gave them samples of plain MSG.

Some of the people who had reported MSG headaches did react when they were given pure MSG. But none of them had any reaction when the MSG was mixed with food.

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Depression May Worsen Age-Related Vision Loss

Reuters Health

Friday, August 16, 2002

NEW YORK (Reuters Health) - Depression is common among older adults whose vision is impaired by macular degeneration, and it may make their vision seem worse than it is, researchers report.

The investigators found that one third of the patients with age-related macular degeneration (AMD) they studied had symptoms of depression. And worsening depression over time was related to a decline in self-reported visual functioning, regardless of actual loss of vision, according to the report published in the August issue of the Archives of Ophthalmology.

AMD is a common cause of deteriorating vision in older adults. Over time there is a breakdown in light-sensitive cells in the macula, the tissue in the center of the retina. AMD can make it difficult to read, drive or perform other activities that require sharp vision.

In the new study, Dr. Barry W. Rovner and colleagues at Thomas Jefferson University in Philadelphia, Pennsylvania followed 51 older patients with recent vision deterioration due to AMD.

At the study's start, 33% were diagnosed with depression. These patients also tended to have worse corrected vision and more general disability than the other AMD patients, the report indicates.

When Rovner's team examined the patients again 6 months later, they found that those whose depression had worsened also had a decline in vision function--meaning they reported more problems with daily activities such as reading newsprint, recognizing faces and watching TV.

However, there was no evidence that this decline in functioning was actually related to worsening visual acuity, the researchers note. They speculate that depression, without actual changes in vision, may spark a functional decline in AMD patients.

"The psychological and (physical) symptoms of depression probably account for its adverse effect on vision function," the study authors write. "Discouragement and helplessness drain inner resolve and resiliency."

However, Rovner and his colleagues add, their findings also suggest that treating AMD patients' depression might help.

"Recognizing that depression is not simply an understandable consequence of vision loss but rather a distinct, treatable disorder is a necessary first step," they conclude.

Source: Archives of Ophthalmology 2002;120:1041-1044.

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THURSDAY, AUGUST 15, 2002

Of Mouse and Man and Cancer

HealthScoutNews

Thursday, August 15, 2002

THURSDAY, Aug. 15 (HealthScoutNews) -- A new finding about a cancer-causing gene called Ras may offer researchers a new target for anti-cancer drugs.

The study appears in today's issue of Genes and Development.

Duke Comprehensive Cancer Center re